Dissimilar populations of EpСam-positive cells in ascitic fluid of ovarian cancer patients: a relationship with the degree of carcinomatosis

Background . Peritoneal carcinomatosis (PC) is one of the most unfavorable factors ovarian cancer progression. It often accompanied by accumulation fluid in abdominal cavity, which called ascites. However, prognostic associated with malignant ascites are not well understood. The aim this study was to evaluate dissimilar populations EpCAM-positive cells ascitic and their relationship presence invasive peritoneal implants prevalence on Predictive Index Value (PIV) scale patients. Materials methods prospective included 22 patients aged 36–76 years newly diagnosed FIGO stage Ic–IV cancer, who were admitted for treatment Cancer Research Institute Tomsk NRMC. material EDTA-stabilized sampled during laparoscopy. Various tumor identified laser multicolor flow cytometry. degree determined according PIV scale. Results. twelve Epcam+CD45-CD44-CD24+CD133-Ncadherin+ ( r = 0.58; p 0.004) atypical (hybrid) EpCam+CD45+CD44+CD24+/-CD133+/-Ncadherin+/- 0.51; р 0.01) had a positive correlation index. Conclusion obtained results show high heterogeneity Identified forms EpCam-positive great interest cell biology require further investigation.